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Torsemide row Na+ effect
May 30, 2018

row Na+ effect


Torsemide inhibits the reabsorption of Na+ and c1- by Heinz crucian carp, whereas the distal renal segment does not completely compensate, resulting in a row of Na+ and a diuretic effect. The threshold dose of row Na+ was 2.5 mg. Within the therapeutic dose range, there was a log-linear response curve between excretion rate of urine Na+ and torasemide. Fowler et al [5] reported that the product 20mg significantly increased the total amount of Na+ in each time period and 24h, while the product 10mg or furosemide 40mg only significantly increased the amount of Na+ in the first 4h. Knauf et al. reported that 20 mg torasemide was intravenously injected into healthy volunteers, and Na+ began to be discharged within 1 h, peaking at 1 h to 2 h, with the most Na+ excretion within 6 h, and thereafter decreasing Na+, lower than the baseline Na+ volume.


Fold row K+ effect


Torsemide's row K+ is weaker than other loop diuretics. Torasamide lacks reabsorption of phosphorus or carbohydrates in the proximal tubules, while K+ reabsorption is also in the proximal tubules, and it is hypothesized that the amount of row K+ will decrease. On the other hand, it may also be related to the anti-aldosterone action of the product, its row K+ action is relatively weaker than its row Na+ action, so urinary Na+/K+ increases. Furosemide has a K+ effect that is 3 times that of the product. However, there was no significant difference between torasemide and furosemide in clinical monitoring of blood K+ and urinary K+.


Fold other effects


Kruck reported that there is no clinically significant change in blood Mg2+ with long-term treatment with torsemide, but Knauf et al. reported that the change of Mg2+ within 24 h after administration is directly related to the row of K+. Therefore, the effect of Mg2+ on the present is not conclusive. During the torasemide effect, the loss of urinary Ca2+ and urinary Cl- was parallel to the excretion of Na+ in the urine. The excretion rates of urinary Ca2+ and cl- in urine within 24 h were not significantly different between 10.20 mg torsezamide and 40 mg furosemide. Blood Ca2+ and blood cl- were unchanged. There was no significant effect on the excretion of uric acid, urea, and creatinine.


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